hyperuricemia
Conditions
Interventions
low-dose group:Febuxostat 20mg/d
normal-dose group:Febuxostat 40mg/d
Control group:Diet and lifestyle intervention
Sponsors
Zhejiang Provincial People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Age 75-100 years old; (2) Meet the diagnostic criteria of stage 3-5 CKD, except the acute kidney injury and dialysis patients; (3) Meet the diagnostic criteria for HUA
Exclusion criteria
Exclusion criteria: (1) Gout attacks in the previous 2 weeks or the use of uric acid lowering drugs or drugs that affect uric acid metabolism or excretion; (2) Abnormal liver function: alanine aminotransferase (ALT), aspartate aminotransferase (AST) > 2 times of the reference value or active hepatitis B, hepatitis C, etc.; (3) Severe heart failure, malignant arrhythmia, acute cardiovascular and cerebrovascular accidents, acute and chronic infections, hematological diseases, active tumors, tuberculosis, HIV, etc., occurred within the previous 3 months; (4) Patients considered unsuitable for inclusion by the investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood creatinine;uric acid;(estimated glomerular filtration rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| (systolic blood pressure;diastolic blood pressure;body mass index;hemoglobin;albumin;low density lipoprotein cholesterol;high density lipoprotein cholesterol;total cholesterol;triacylglycerol;cardiac troponin I;brain natriuretic peptide;left ventricular ejection fractions;brachial-ankle pulse wave veloity;creatinine clearance rate; | — |
Countries
China
Contacts
Public ContactXiuxiu Lai
Zhejiang Provincial People's Hospital
Outcome results
None listed