Preliminary exploratory study on the antithrombotic effect of tirofiban in stent assisted embolization of ruptured aneurysms.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200067188

Enrollment

Unknown

Registered

2022-12-29

Start date

2022-12-30

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ruptured intracranial aneurysm

Interventions

Control group:Oral loading dose double antibody before interventional embolization of ruptured intracranial aneurysm.

Experimental group1:Interventional embolization of ruptured intracranial aneurysms perioperative use of tirofiban.

Experimental group2:Intravenous application of tirofiban in perioperative period.

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) The subarachnoid hemorrhage was diagnosed by CT, (2) DSA angiography or CTA examination showed that there was rupture of intracranial aneurysm, (3) The patient or his family members agreed to perform stent assisted interventional embolization of intracranial aneurysms, (4) The patient or his family members agree to use antiplatelet drugs, (5) When signing the informed consent form, there is no limit to men and women aged 18-80,

Exclusion criteria

Exclusion criteria: (1) The patient is allergic to any component of tirofiban, (2) Recent (within 1 year) bleeding, including gastrointestinal bleeding or clinically significant urogenital bleeding, (3) Known history of coagulopathy, platelet abnormalities, or thrombocytopenia, (4) Platelet count is less than 150000mm/3, (5) History of cerebrovascular disease within 1 year, (6) Recent epidural surgery, (7) Severe uncontrolled hypertension (systolic blood pressure greater than 180mmHg and/or diastolic blood pressure greater than 110mmHg), (8) Hemorrhagic retinopathy, (9) Chronic hemodialysis, (10) History of major surgery or severe physical trauma within 1 month, (11) Patients with lobar hematoma due to aneurysm rupture and midline displacement greater than 1cm who need decompressive craniectomy, (12) On admission, CT showed clear hydrocephalus, and patients needed to open the external drainage of the operating ventricle,

Design outcomes

Primary

Measure	Time frame
Effectiveness;	—

Secondary

Measure	Time frame
Safety;	—

Countries

China

Contacts

Public ContactHongping Miu

The First Affiliated Hospital of Army Medical University,PLA

wksalm@163.com13320293522

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026