Abdominal surgery for elderly patients
Conditions
Interventions
Subanesthetic dose of esketamine group:Intravenous push of 0.25mg/kg esketamine before induction,Intraoperative injection was maintained with 0.1mg/kg/h Esketamine.
Physiological saline group:Intravenous push of equal amount of saline before induction,Intraoperative pumping was maintained with 0.1mg/kg/h normal saline.
Sponsors
Chaohu Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Elective abdominal surgery under general anesthesia. 2.Age: 65~85 years old. 3.ASA classification I~III. 4.BMI 18~25 kg/m2. 5.Able to independently complete all preoperative cognitive function test. 6.Know and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.combined neuropsychiatric disorders, communication disorders. 2.severe liver and kidney dysfunction. 3.history of severe hypertension, diabetes mellitus and coronary artery disease. 4.preoperative summary mental status examination (MMSE) score <24. 5.Refusal to sign the informed consent form due to other factors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini-mental State Examination(MMSE) score;Incidence of perioperative neurocognitive disorders(PND);Incidence of postoperative delirium(POD); | — |
Secondary
| Measure | Time frame |
|---|---|
| Levels of IL-2?IL-6 and TNF-a;MAP?HR?SPO2?BIS value;VAS score;Ramsay sedation score;Dose of opioid use;Whether there is a body motion reaction during the transverse abdominis plane block;Incidence of perioperative adverse reactions; | — |
Countries
the People's Republic of China
Contacts
Public ContactXia Xiaoqiong
Chaohu Hospital of Anhui Medical University
Outcome results
None listed