Anxiety insomnia
Conditions
Interventions
Right metformin group:Dexmedetomidine nasal drip + oral vitamin C
Lorazepam group:Saline nasal drip + oral lorazepam
Placebo group:Saline nasal drip + oral vitamin C
Sponsors
The first affiliated hospital of Gannan Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: a. ASA classification I to II b. Hospital Anxiety and Depression Scale (anxiety component) HADS-A > 7 points c. Insomnia Severity Index (ISI) >7 points d. Patients with oxygen saturation of 95% or more on air inhalation e. Patients 18-65 years of age, regardless of gender, who are to undergo elective surgery f. Voluntary signed informed consent
Exclusion criteria
Exclusion criteria: a. Hospital Anxiety and Depression Scale (depression component) HADS-D > 7 b. NRS pain score = 7. c. Presence of alcohol or drug dependence d. use of psychotropic drugs within 1 week prior to enrollment e. BMI > 30kg/m2 f. patients with confirmed or suspected presence of apnea syndrome g. Presence of any intranasal lesions or congenital abnormalities in the nose. h. Abnormalities in ECG, liver and kidney function. i. History of allergy to the drugs used in the study. j. Pregnancy, lactation and plans to become pregnant in the short term. k. Those who are unable to understand the content of the relevant scale or have severe visual impairment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to fall asleep;total sleep time;Psychomotor alertness tasks;Leeds sleep rating scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep Quality Digital Rating Scale;mean arterial pressure;heart rate;Blood pressure saturation;adverse reaction; | — |
Countries
China
Contacts
Public ContactLi Chen
The first affiliated hospital of Gannan Medical College
Outcome results
None listed