Refractory cardiogenic shock
Conditions
Interventions
intervention group:ultra-protective tidal volume
control group:protective tidal volume
Sponsors
jiangsu province hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria target 18 years and older patients receiving VA-ECMO therapy including extracorporeal cardiopulmonary resuscitation(ECPR). Key inclusion criteria also include: (1)onset of IMV more than 72h; (2)not pregnant; (3)with ECMO duration of more than 72h; (4)RCS or CA with cardiac origin; (5)not enrolled in another clinical trial; (6)signing informed consent form by the guardian; (7)description of CPE on high-resolution chest CT by two radiologists with at least 5-year diagnostic experience who are unaware of the clinical diagnosis.
Exclusion criteria
Exclusion criteria: The exclusion criteria for patient enrollment are as follows: (1)trauma; (2)lack of writtten informed consent by next of kin; (3)existence of contraindications for fiberoptic bronchoscopy examination; (4)blurry lung ultrasound image; (5)pneumothorax and massive pleural effusion; (6)use ECMO as a bridge to heart transplantation; and (7) the patients develop adverse events contributed to difficult weaning from IMV(e.g., intracranial hemorrhage, thromboembolism, severe infection).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the number of ventilator-free days(VFD) at day 28 after inclusion; | — |
Secondary
| Measure | Time frame |
|---|---|
| respiratory mechanics;lung ultrasound score;pro-inflammatory mediators; total length in day for ECMO weaning;length of stay(LOS) in intensive care unit;LOS in hospital;in-hospital mortality; | — |
Countries
China
Contacts
Public Contactchen xufeng
jiangsu province hospital
Outcome results
None listed