patients with loss of consciousness under general anesthesia
Conditions
Interventions
Remazolam 0.1mg/kg:Remazolam 0.1mg/kg
Remazolam 0.15mg/kg:Remazolam 0.15mg/kg
Remazolam 0.2mg/kg:Remazolam 0.2mg/kg
Remazolam 0.25mg/kg:Remazolam 0.25mg/kg
Remazolam 0.3mg/kg:Remazolam 0.3mg/kg
Propofol 1.0mg/kg:Propofol 1.0mg/kg
Propofol 1.5mg/kg:Propofol 1.5mg/kg
Propofol 2.0mg/kg:Propofol 2.0mg/kg
Propofol 2.5mg/kg:Propofol 2.5mg/kg
Propofol 3.0mg/kg:Propofol 3.0mg/kg
Sponsors
Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
2 Years to 18 Years
Inclusion criteria
Inclusion criteria: (1) American Society of Anesthesiologists (ASA) Grade I-II; (2) Age < 18 years old; (3) Patients undergoing elective surgery requiring general anesthesia; (4) No history of systemic disease (5) Get permission from parents or guardians (sign informed consent form)
Exclusion criteria
Exclusion criteria: (1) Patients undergoing hepatectomy or liver transplantation; (2) Abnormal liver function and history of other systemic diseases; (3) Patients with liver disease (liver disease history, bilirubin =3.0 mg/dl, or aspartic aminotransferase/alanine aminotransferase =2.5 times the upper limit of normal); (4) patients with nephropathy (serum creatinine =2 mg/dl); (5) Intolerance or allergy to benzodiazepines; (6) History of drug addiction; (7) Children who planned to undergo local anesthesia before anesthesia induction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time of loss of consciousness; | — |
Countries
CHINA
Contacts
Public ContactYang Shen
Shanghai Children’s Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed