Dose exploration of phosphopropofol disodium for anesthesia induction in elderly orthopedic surgery patients with knee replacement

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200067109

Enrollment

Unknown

Registered

2022-12-27

Start date

2023-01-01

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

orthopedic disorders

Interventions

P group:Disodium phosphopropofol

M group:Disodium phosphopropofol + midazolam

Eligibility

Sex/Gender

All

Age

65 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1)Choose knee replacement surgery; 2)ASA (American Society of Anesthesiologists Classification) I–III 3)All the patients provided written informed consentundergoing elective knee replacement 4)65y =Age =80y.)

Exclusion criteria

Exclusion criteria: 1)Schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis patients; 2)Patients with difficulty in communication due to coma, severe dementia, speech impediment, or unable to cooperate due to other diseases; 3)People with craniocerebral trauma or other craniocerebral diseases; 4)Sedative and analgesic drugs were used within 3 hours before surgery.

Design outcomes

Primary

Measure	Time frame
Satisfactory induction of anesthesia;	—

Secondary

Measure	Time frame
The time required for BIS to reach 60 after injection of disodium phosphopropofol;Postoperative recovery time;Intraoperative complications;Incidence of postoperative delirium;postoperative nausea and vomiting;	—

Countries

China

Contacts

Public ContactKeqiang He

The First Affiliated Hospital of USTC

doctorhector@ustc.edu.cn18955197569

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026