COVID-19 Pneumonia
Conditions
Interventions
Glucocorticoids treatment group:Glucocorticoids treatment
Control group:Standard treatment
Sponsors
Chongqing University Three Gorges Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with common type COVID-19 pneumonia, aged = 18 years old. 2. The Ct value of either N gene or ORF gene of COVID-19 nucleic acid testing reaches 33, and meets one of the following two conditions: 1) The chest CT score of COVID-19 pneumonia is aggravating; 2) The chest CT score of COVID-19 pneumonia = 10 and without absorption. 3. Voluntarily sign the informed consent form; if the patient is incapable of autonomous behavior, the guardian shall sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Contraindications to the use of glucocorticoids. 2. Expected survival time = 3 days. 3. Severe and critical patients with new coronary pneumonia. 4. Patients with positive influenza virus nucleic acid. 5. Patients with bacterial pneumonia as the main imaging manifestation. 6. Patients who had interstitial lung disease in the past and were in the active stage at the time of admission. 7. Patients with obvious abnormal changes in lung structure such as pneumoconiosis and severe bronchiectasis. 8. Pregnancy and perinatal women. 9. Immunodeficiency patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change in chest CT score; | — |
Secondary
| Measure | Time frame |
|---|---|
| change in COVID-19 nuclear acid cycle threshold value;change in COVID-19 antibodies;duration of hospital stay and ICU stay, mortality rate;rate of severe and critical disease;side effect of glucocorticoids; | — |
Countries
China
Contacts
Public ContactHuawen Liu
Chongqing University Three Gorges Hospital
Outcome results
None listed