Brain injury
Conditions
Interventions
VNM group:Magnetic stimulation of vagus nerve
Sponsors
The Second Clinical Hospital of North of Sichuan University · Nanchong Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) stroke; Inclusion criteria:?1patient age 18-65 years old, right-handed;?2cerebral infarction or cerebral hemorrhage;?3 The diagnosis is in line with the key points of diagnosis of various major cerebrovascular diseases in China 2019;?4Stroke confirmed by head CT or MRI examination. (2) craniocerebral injury; Inclusion criteria: ?1patient age 18-65 years old, right-handed; ?2Clarify the history of craniocerebral injury; ?3Transcranial CT or MRI Examination reveals brain contusions, (traumatic) parenchymal hemorrhage, diffuse axonal injury, and other injuries involving the brain parenchyma. (3) The Montreal Cognitive Assessment (MoCA) scale assesses the existence of cognitive workenergy impairment, scored < 26 points; (4) No history of epilepsy; (5) Unstable vital signs (respiratory or hemodynamic instability) with severe heart, liver, kidneys or lungsinjury or other serious illness; (6) Central stimulant drugs are not used for treatment; (7) The patient himself or his legal representative signs the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Contraindications to magnetic stimulation, the presence of metal foreign bodies and electronic devices within 30cm of the treatment site, such as cochlear implants, pacemakers, metal foreign bodies in the head or neck (metal tracheal intubation patients), etc.; (2) Intracranial pressure > 30mmHg, intracranial active bleeding; (3) Primary or metastatic brain tumors; (4) previous history of vagus nerve section; (5) metabolic diseases, including anemia, thyroid dysfunction, folate and vitamin B12 deficiency, which may lead to cognitive decline; (6) Patients who are unable to cooperate with the therapist to complete the assessment and intervention.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment,MoCA;CNS specific protein (S100ß);anti-ganglionic Acetylcholine receptors antibody; | — |
Secondary
| Measure | Time frame |
|---|---|
| Improved Barthel Index (MBI); | — |
Countries
China
Contacts
Public ContactZhang Han
Nanchong Central Hospital
Outcome results
None listed