Ischemia-reperfusion injury
Conditions
Interventions
C group:Before induction of anesthesia, general anesthesia was performed after ultrasound-guided femoral nerve block
DEX group:Before induction of anesthesia, general anesthesia was performed after ultrasound-guided femoral nerve block. Dexmedetomidine 0.8µg/kg was pumped intravenously for 10min 15min before inducti
ERIPC group:Before induction of anesthesia, ultrasound-guided femoral nerve block was performed, and then general anesthesia was performed. After induction of anesthesia, orthopedic tourniquet was tie
LRIPC group:An orthopedic pressure tourniquet was placed on the lower extremity 24 h before surgery and inflated to 200 mmHg for 5 min and deflated for 5 min. Three cycles were repeated
Sponsors
The Third Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients undergoing TKA under general anesthesia; (2) Voluntarily sign the informed consent; (3) ASA Grade I to III; (4) BMI 18-28 kg/m2
Exclusion criteria
Exclusion criteria: (1) Congenital heart disease or history of cardiac surgery, heart conduction disease, frequent ventricular/atrial premature beats, atrial fibrillation and other serious arrhythmias; (2) Severe liver disease and kidney disease; (3) Temporary and permanent pacemaker implantation; (4) Patients with serious central nervous system diseases or serious mental disorders; (5) Recent history of sedation, antidepressant or opioid use; (6) Body mass index >35kg/m2; (7) Participants in other clinical trials within 1 month prior to study enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SOD;MDA;IL-6;TNF-a;hs-Tn;BDNF; | — |
Countries
China
Contacts
Public ContactXiu-Li Wang
The Third Hospital of Hebei Medical University
Outcome results
None listed