ischemic stroke
Conditions
Interventions
Test Group:Clopidogrel 75mg/day for 90 days
Aspirin 100mg/day for 90 days
Control Group:Clopidogrel 75 mg/day for 30 consecutive days
Aspirin 100 mg/day for 90 consecutive days
Sponsors
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 40 to 75 years old; 2. In line with the WHO definition of stroke, patients with non-cardiac cerebral infarction, those with hemorrhagic cerebral infarction were excluded by head CT/MRI and confirmed as cerebral infarction, and intracranial arterial stenosis was >50% confirmed by MRA/CTA/DSA (intracrnial internal carotid artery, major branches of middle cerebral artery (M1, M2 proximal segment), anterior cerebral artery (A1 segment), posterior cerebral artery (P1 segment), intracranial vertebral artery and basilar artery); 3. The onset of the first stroke is less than 7 days; 4. NIHSS score = 3 points; 5. The patient or family members signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients receiving thrombolysis and thrombectomy; 2. Patients with a history of recurrent stroke; 3. Patients with major surgery or severe trauma in the previous 30 days; 4. history of gastrointestinal bleeding, active peptic ulcer, intracranial hemorrhage, other bleeding diseases 5.contraindication or intolerance of antiplatelet agents 6. platelet count & Lt 100 * 10 ^ 9/L, hemoglobin & LT; 110 g/L; 7. The patients with severe heart, lung, liver and kidney insufficiency and serious combined diseases (for example, severe heart and lung failure, advanced tumor, severe dementia) 8.The patients with poor compliance can not cooperate with the demands of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 3-month major ischemic events and major bleeding events, including death from cardiovascular and cerebrovascular disease, myocardial infarction, stroke (including ischemic and hemorrhagic), emergency intervention and bleeding academic research alliance criteria (BARC) grade 2 or higher bleeding .; | — |
Secondary
| Measure | Time frame |
|---|---|
| Separate major ischemic events (including myocardial infarction + cerebral infarction), myocardial infarction, cerebral infarction, major bleeding event, disability (mRS>2), cardiovascular and cerebrovascular death or death.; | — |
Countries
China
Contacts
Public ContactNengwei Yu, JieYang, Fuqiang Guo
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
Outcome results
None listed