Alzheimer's disease
Conditions
Interventions
Test group:All subjects were given computerized cognitive training combined with oral treatment with sodium mannitol capsules.
Sponsors
Affiliated Zhongshan Hospital of Dalian University
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: ? Male or post-menopausal female patients aged 60-85 years (inclusive). ? Meeting the diagnostic criteria issued by the National Institute on Aging (NIA) and the Alzheimer's Association (AA) in 2011 (referred to as NIA-AA diagnostic criteria). ? Patients with mild to moderate Alzheimer's disease (AD), i.e., a total score of 11 = MMSE = 26 on the Mini-mental State Examination Scale (MMSE) (11 = MMSE = 22 for subjects with elementary school education). = 22 points). ? A score of =4 on the Hachinski Ischemia Scale. ? Subjects with elementary school education or above and the ability to complete the cognitive ability measurements and other tests specified in the protocol. ? having a regular guardian or caregiver, and the caregiver will use a tablet computer to assist the patient in cognitive training and other operations. (vii) Patients who voluntarily purchase and take Mannitol sodium capsules. ? Patients who voluntarily participate in remote home cognitive training. ? Signed written informed consent (or signed by the patient's caregiver with the patient's authorization).
Exclusion criteria
Exclusion criteria: ?Those diagnosed as non dementia or severe dementia after baseline survey; ? There is a clear history of cerebrovascular stroke, and there are clear symptoms or signs of neurological impairment at the time of onset, and there are corresponding responsible lesions left on neuroimaging; ? Suffering from consciousness disorder caused by any reason; ? Those who are unable to complete neuropsychological examination due to severe aphasia or physical disability; ? People with depression or mental illness; ? People with a history of alcoholism, drug addiction, or neurological diseases that can cause cognitive impairment such as brain trauma, epilepsy, encephalitis, normal intracranial pressure hydrocephalus; ? Having systemic diseases that may lead to dementia (such as liver and kidney dysfunction, endocrine diseases, vitamin deficiency); ? Patients with contraindications to the use of mannite sodium, or patients who have started to take mannite sodium in the past; ? Patients who refuse to participate in home distance cognitive training; ? Patients who refuse to take blood; ? Those who refuse to complete MRI examination; ? Those with contraindication of magnetic resonance examination; ? Patients who refused to participate in the clinical study.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Alzheimer Disease Collaborative Study-Activities of Daily Living Questionnaire; | — |
Countries
China
Contacts
Public ContactMa Qiang
Affiliated Zhongshan Hospital of Dalian University
Outcome results
None listed