Bipolar Disorder
Conditions
Interventions
BLT group in BD-DEP:BLT
sham BLT group in BD-DEP:sham BLT
Sponsors
Hangzhou Seventh People’s Hospital
Eligibility
Sex/Gender
All
Age
16 Years to 50 Years
Inclusion criteria
Inclusion criteria: (1) patients were received SCID-5-CV interview, meeting the DSM-5 criteria for BD (type I or type II). (2) 16-50 years of age. (3) had history of medication of Mood stabilizers (the list of firstly recommended mood stabilizers (such as lithium carbonate, valproate, or second-generation antipsychotics) at a therapeutic dose according to the Chinese Guidelines for the Prevention and Treatment of Bipolar Disorder (the second edition)) at least 2 weeks before recruited. (4) had a Hamilton Depression Scale (version: 17 Items; HAMD-17) total score=18. (5) Han nationality, right-handed, education of primary school, IQ>70, and ability of understanding the neuropsychological test. (6) volunteered to participate in this study and signed the informed consent.
Exclusion criteria
Exclusion criteria: (1) a history of or current serious physical diseases, organic brain diseases, and nervous system diseases. (2) a history of or current other psychiatric disorders other than bipolar disorder, including neurodevelopmental disorders, schizophrenia or other psychiatric disorders, depressive disorders, anxiety disorders, abuse of or dependence on substances. (3) color blindness, color weakness affecting neurocognitive testing, or any contraindications for MRI. (4) IQ=70. (5) a history of or current retinodystrophy, age-related macular degeneration, porphyria, chronic actinic dermatitis, solar urticaria and other diseases. (6) for women, pregnancy, or planned pregnancy in recent three months. (7) had a history of other interventions such as electroconvulsive therapy and transcranial magnetic stimulation in recent 3 months. (8) inconsistent with or cannot effectively complete the treatment plan.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD-17 score;brain blood oxygen level dependence;brain electrophysiological signals;Concentration information of neurotransmitters and metabolites;Genotyping;brain structure;Biorhythm; | — |
Secondary
| Measure | Time frame |
|---|---|
| cortisol;melatonin; | — |
Countries
China
Contacts
Public ContactLi Tao
Hangzhou Seventh People’s Hospital
Outcome results
None listed