polycystic ovary syndrome
Conditions
Interventions
Fetal microbiota transplantation combined with lifestyle intervention group:Fetal microbiota transplantation combined with lifestyle intervention
Sponsors
Shanghai tenth people's hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Women older than 18 and younger than 45 Meet Rotterdam PCOS diagnostic criteria Overweight or obese, BMI = 25kg/m2
Exclusion criteria
Exclusion criteria: Patients with gynecological or gastrointestinal cancer history or family history; Patients with type 1 and type 2 diabetes or diabetes ketoacidosis; Pregnant women; Uncontrolled hypertension (systolic/diastolic blood pressure 140/90mmHg) Active heart disease occurred within 3 months; Inflammatory bowel disease, diabetes gastritis or other serious gastrointestinal diseases; For liver diseases, AST or ALT levels are twice higher than the upper normal limit; For kidney disease, the creatinine clearance rate is lower than 60mL/min; Active or untreated malignant tumor; Combined with intestinal organic or functional diseases; The use of drugs that may interfere with the test results is being used (metformin, Diane 35, etc.) Have received surgical treatment for obesity or FMT treatment; Long term smoking or use of any nicotine product; Alcoholism; Those who need pregnancy and refuse to take reliable contraceptive measures during the study period; Currently or recently participating in another clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| weight;Intestinal flora; | — |
Secondary
| Measure | Time frame |
|---|---|
| waist;hipline;E2;FSH;LH;T;PRL;P;AMH;Glu;insulin;serum cholesterol;triglyceride;HDL;LDL;HOMA-IR;menstrual cycle;ovulation;Androstenedione;DHEA;Sex hormone binding protein;DXA;fibro scan;creatinine;ALT;AST;Urea nitrogen;uric acid;Gynecologic ultrasound; | — |
Countries
China
Contacts
Public ContactXiaowen Shao
Shanghai tenth people's hospital
Outcome results
None listed