Sedation in ICU Patients with Mechanical Ventilation
Conditions
Interventions
Group ciprofol:ciprofol sedation
Group propofol:propofol sedation
Sponsors
Shanghai Fourth People's Hospital Affiliated to Tongji University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) 18 years = age = 85 years, 18 kg / m2 = BMI = 30 kg / m2, gender unlimited; (2) Before enrollment, patients were intubated, mechanically ventilated for no more than 96 hours, expected to receive sedation for = 24 hours, and sedation target RASS score: - 3 to 0 points; (3) The patients' families will fully understand the purpose and significance of the trial, participate voluntarily and sign the informed consent form;
Exclusion criteria
Exclusion criteria: (3) Acute severe neuropsychiatric disease and various conditions interfering with RASS scores; (4) Systolic blood pressure remains less than 90 mmHg with high doses of a single vasoactive drug to maintain blood pressure or two or more vasoactive drugs to maintain blood pressure; (5) Heart rate less than 50 beats / min, second - or third degree heart block and no pacemaker; (6) Cardiac function class IV (NYHA class) or severe cardiomyopathy; (7) Severe liver dysfunction or acute liver failure; (8) Chronic alcohol or drug use; (9) Patients with known allergies to eggs, soy products, or propofol and patients with contraindications to propofol, opioids, and their reliever medications; (10) Had contraindications to deep sedation, or had a previous sedation accident; (11) Pregnant or lactating women; (12) The investigator considered the evaluation of the patient as not suitable for inclusion in the study for various reasons;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of time on qualified sedation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart Rate;Blood Pressure;Inflammatory biomarkers; | — |
Countries
China
Contacts
Public ContactSun Xiaoxiao
Shanghai Fourth People's Hospital Affiliated to Tongji University
Outcome results
None listed