Multiple injuries,Sepsis
Conditions
Interventions
Experimental group:Contains PHGG enteral nutrition
Sponsors
Northern Jiangsu People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 ~ 70 years; 2. Meet the diagnostic criteria for multiple injuries and have an ISS score of > 16 points on admission; 3. Be at risk of malnutrition after nutritional screening and have indications for nutritional support; 4. Start EN within 5 days of injury; 5. The patient has no prior history of malnutrition or diabetes; 6. The patient has no functional digestive system disease in the last 6 months; 7. Informed consent for this study signed by the patient's immediate family or guardian upon admission.
Exclusion criteria
Exclusion criteria: 1. The trauma patient is admitted to the hospital without an immediate family member or guardian; 2. Pregnancy and obesity (body weight > 150 per cent ideal body weight); 3. A previous history of HIV infection, immunosuppressive disease or immunosuppressive therapy; 4. The terminal stage of various diseases, such as malignant tumors, cancer and other diseases; 5. Exclude patients with previous hyperthyroidism, cirrhosis and other diseases; 6. Use of antibiotics, hormones or immunosuppressants, oral probiotics, prebiotics, etc. in the past month; 7. Patients with infectious diseases prior to admission; 8. Those who are allergic to milk protein; 9. Other healthcare professionals who deem it inappropriate to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Enteral nutrition tolerance score on day 7; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sepsis incidence during ICU;Day 7 nutritional status;Fecal probiotic content on day 7;Day 28 quality of life score;Length of ICU stay;Duration of mechanical ventilation;28-day mortality; | — |
Countries
China
Contacts
Public ContactDingyu Tan
Northern Jiangsu People's Hospital
Outcome results
None listed