autoimmune encephalitis
Conditions
Interventions
Index test:TSPO-PET
Sponsors
Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: AE patients 1) Diagnosed as antibody-positive autoimmune encephalitis according to clinical guidelines or diagnostic criteria; 2) Age from 18 years old to 80 years old, without sex restriction; 3) Promise to complete the study and follow-up as planned, and the patient and/or guardian (when the patient is unconscious) can understand the study and sign the informed consent form. Healthy control 1) No previous history of encephalitis and family history related to encephalitis; 2) No obvious abnormality was found in physical examination.
Exclusion criteria
Exclusion criteria: Exclusion criteria for AE patients: 1) Diagnosed diseases of the central nervous system that lead to epilepsy, cognitive impairment or abnormal mental symptoms, including Alzheimer's disease, Parkinson's disease, central nervous system tumors, schizophrenia, etc, in recent 5 years. Patients with other system tumor diseases should not be excluded; 2) Lactating and/or pregnant women; 3) History of brain surgery; 4) Patients with serious medical diseases (such as heart, liver, lung and kidney insufficiency); 5) Patients unable to cooperate with the examination due to severe mental and behavioral abnormalities, central respiratory failure, etc; 6) The researchers believe that the subjects may not be able to complete the study or may not be able to comply with the requirements of the study; Healthy control 1) Diagnosed diseases of the central nervous system that lead to epilepsy, cognitive impairment or abnormal mental symptoms, including Alzheimer's disease, Parkinson's disease, central nervous system tumors, schizophrenia, etc, in recent 5 years. 2) Suffering from tumor disease; 3) People with severe liver and kidney dysfunction, cardiopulmonary failure, blood system diseases, and severe systemic infectious diseases; 4) Suffering from mental illness. 5) The researchers believe that the subjects may not be able to complete the study or may not be able to comply with the requirements of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Specificity;SUVmean of TSPO;Correlation between TSPO and FDG uptake; | — |
Countries
China
Contacts
Public ContactYong Hao
Outcome results
None listed