Neuromyelitis Optica Spectrum Disorders and Myelin oligodendrocyte glycoprotein antibody disease
Conditions
Interventions
Gold Standard:Antibody test
Sponsors
Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria of NMOSD patients: (1) Age: 18-75; (2) Conformed diagnosis (according to 2015 NMOSD international consensus), and the AQP4 antibody test positive; (3) During the acute stage of the disease, and within 30 days from this attack to PET/MR; (4) EDSS score = 8; (5) Normal liver and kidney function, blood test, urine routine test and other biochemical tests; (6) Able to complete follow-up; (7) Intracranial lesions exist according to MRI examination or symptoms and signs; (8) The patient or families signs the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Allergy of related imaging agents; (2) Diagnosed diseases of the central nervous system that lead to epilepsy, cognitive impairment or abnormal mental symptoms, including Alzheimer's disease, Parkinson's disease, central nervous system tumors, schizophrenia, etc; (3) Lactating or pregnant women in 5 years; (4) History of brain surgery; (5) Patients with serious medical diseases (such as heart, liver, lung and kidney insufficiency); (6) Patients with abnormal expression or disturbance of consciousness, unstable vital signs, and unable to cooperate with the examination due to severe mental and behavioral abnormalities, central respiratory failure, etc; (7) The researchers believe that the subjects may not be able to complete the study or may not be able to comply with the requirements of the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SUV of FDG; | — |
Secondary
| Measure | Time frame |
|---|---|
| SUV of FDG;SUV of Acetate;Sensitivity;Specificity; | — |
Countries
China
Contacts
Public ContactYangtai Guan
Outcome results
None listed