laparoscopic colorectal surgery
Conditions
Interventions
Control Group:0.25% ropivacaine 20ml/one side, i.e. 10mL ropivacaine+normal saline to 40mL
Dexamethasone Group:0.25% ropivacaine+5mg dexamethasone 20ml/one side, i.e. 10ml ropivacaine+10mg dexamethasone+normal saline to 40mL
Hydromorphone Group:0.25% ropivacaine+1mg hydromorphone 20ml/one side, i.e. 10ml ropivacaine+2mg hydromorphone+normal saline to 40mL
Sponsors
Peking University, Shougang Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) Age 18-70; 2) ASA Class I-III; 3) General anesthesia for laparoscopic colorectal surgery; 4) BMI is 18.5-29.9kg/m2 [BMI=weight (Kg)/height (m) 2]; 5) In line with ethics, the patient volunteered to be tested and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Patients who are allergic to the study drug; 2) Severe abnormal liver and kidney function (severe abnormal liver function: ALT, conjugated bilirubin, AST, ALP, total bilirubin, one of which is more than twice the upper limit of normal value; severe abnormal renal function: Cr clearance rate<30 ml/min); 3) Patients with New York Heart Association Class II or above; 4) Severe respiratory diseases; 5) History of chronic pain; 6) Infected persons at injection site; 7) Alcohol or drug abusers; 8) Opioid drug addicts; 9) Patients with mental disorders that interfere with pain perception and assessment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time to the first request for analgesics; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score at rest;VAS score at rest;VAS score during exercise;Opioid consumption;Patient satisfaction;pruritus;Overall QoR-15 score;Nausea and vomiting score;Respiratory depression;Postoperative exhaust time;Drainage tube extubation time;length of stay; | — |
Countries
China
Contacts
Public ContactZhao Lin
Peking University, Shougang Hospital
Outcome results
None listed