The Synergistic Effect and Mechanism of Aerobic Exercise Combined with Cognitive Training in Improving Cognitive Impairment of Subjects with Cerebrovascular Disease

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200066899

Enrollment

Unknown

Registered

2022-12-21

Start date

2023-01-01

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral small vessel disease

Interventions

aerobic exercise group:aerobic exercise

cognitive training group:cognitive training

ACT group:aerobic exercise combined with cognitive training

Control:None

Eligibility

Sex/Gender

All

Age

50 Years to 70 Years

Inclusion criteria

Inclusion criteria: ? Patients may show dizziness, dizziness, memory loss, slow reaction, abnormal gait, balance disorder, depression or anxiety; ? At least one of the signs of white matter hyperintensity (WMH), cavity infarct, subcortical small infarct, cerebral microbleeds (CMB) and perivascular space (PVS) enlargement appears in the head MRI image, and the CSVD total brain imaging load score is = 1; ? Objectively existing cognitive impairment, but not reaching the dementia state defined in the fifth edition of the Diagnostic and Statistical Manual of Mental Diseases (DSM-V); ? Clinical Dementia Rating Scale (CDR) score=0.5; ? Mini mental State Examination (MMSE) score = 24; ? The ability of daily living is normal, and the activity of daily living (ADL) is within the normal range matching the age and education level.

Exclusion criteria

Exclusion criteria: ? AD, Parkinson's disease, Lewy body dementia and other cognitive disorders; ? There is a history of ischemic stroke and the diameter of cerebral infarction is>15mm, or there is a history of cardiogenic cerebral infarction; ? Multiple sclerosis, radiation brain injury, optic neuromyelitis and other diseases, as well as other white matter diseases caused by poisoning, immunity, metabolism, infection and other factors; ? Intracranial hemorrhage, brain trauma, brain tumors and mental system diseases, as well as serious physical diseases, such as thyroid diseases, anemia, malignant tumors, etc; ? Serious visual abnormality, hearing impairment, hemiplegia and other factors lead to the failure of clinical evaluation.

Design outcomes

Primary

Measure	Time frame
Cognitive function;	—

Countries

China

Contacts

Public ContactQing Ye

Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University

yeqingyouxiang@126.com+86 18051060913

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026