Allergic Rhinitis
Conditions
Interventions
the effective group:Allergen-Specific Immunotherapy, AIT
the noneffective group:Allergen-Specific Immunotherapy, AIT
Sponsors
the First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
6 Years to 12 Years
Inclusion criteria
Inclusion criteria: Subjects eligible for inclusion in this study must meet all of the following criteria: 1. Children with allergic rhinitis receiving allergen specific immunotherapy. 2. Gender is not limited, age = 6 years old and = 12 years old. 3. Allergen test confirmed that it was a single dust mite allergy, with or without 1-2 other allergens. 4. Moderate to severe persistent allergic rhinitis with or without allergic conjunctivitis, atopic dermatitis and mild to moderate asthma that occurs all year round. 5. There was no history of tonsillectomy. 6. There was no history of adenoidectomy. 7. No acute fever, infection, oral and oropharyngeal pain and ulcer. 8. Did not participate in other clinical studies. 9. Prior to the start of the study, the informed consent form must be signed by the legal guardian of the child patient.
Exclusion criteria
Exclusion criteria: Subjects who meet any of the following criteria shall not be included in this study: 1. Uncontrolled stable or severe asthma [forced expiratory volume in the first second (FEV1) < 70% predicted value] and irreversible airway obstructive lesions. 2. Active stage of immune disease. 3. Combined with malignant tumor. 4. In use ß Receptor blockers or angiotensin enzyme inhibitors. 5. Serious cardiovascular disease (the risk of using epinephrine may be increased when serious adverse reactions occur). 6. Serious mental system diseases or poor compliance (including those who can not understand the long-term and necessity of treatment, and often can not return to the clinic on time). 7. Primary or secondary immunodeficiency. 8. Serious adverse reactions have occurred during immunotherapy. 9. Patients who refused to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Adenoid hypertrophy;Tonsil hypertrophy;Polysomnography;Total Nasal Symptoms Scores;Rhinoconjunctivitis Quality of Life Questionnaire;Total Medication Score;Visual Analogue Scale;Adenoid face;CRS;Secretory otitis media;hypertrophic inferior turbinate;Deviation of nasal septum;Olfactory disorder;mouth breathing;Upper airway volume;PSQ; | — |
Countries
China
Contacts
Public ContactJisheng Liu
Department of Otolaryngology Head and Neck Surgery,the First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou
Outcome results
None listed