Pancreatic cancer
Conditions
Interventions
Experimental group:?Patients receive relatively sensitive chemotherapy regimen based on the results of organoid drug screening
Control group:Chemotherapy regimens will be formulated by oncologists or pancreatic surgeons according to guidelines for pancreatic cancer and the patient's condition.
Sponsors
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Patients have good compliance, can understand the study process, and signed the written informed consent; (2) age =18 years old and =70 years old; (3) patients with a histopathological or cytological diagnosis of pancreatic ductal adenocarcinoma, or a clinical diagnosis of pancreatic ductal adenocarcinoma Of the patients; (4) ECOG=1; (5) predicted survival time=3 months; (6) expected radical resection of the tumor; (7) no distant metastasis; (8) no history of neoadjuvant chemoradiotherapy; (9) There were no serious systemic complications.
Exclusion criteria
Exclusion criteria: (1) patients with other malignant tumors or received antitumor therapy in the past 5 years; (2) non-pancreatic ductal adenocarcinoma confirmed by postoperative pathology; (3) patients unable to receive chemotherapy due to postoperative complications or poor physical status; (4) patients of childbearing age who are pregnant or lactating or who refuse to use appropriate contraception during the course of the trial; (5) having participated in other trial investigators within 30 days; (6) patients with failure of organoid model construction or failure of drug screening experiments due to various reasons; (7)Patients who were deemed by the investigator to be ineligible for the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| One-year survival rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Disease-free survival;Overall survival; | — |
Countries
China
Contacts
Public ContactZhang Taiping
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Outcome results
None listed