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A multi-center retrospective clinical study about PTRF/Cavin-1 predicting TMZ chemotherapy sensitivity in IDH wildtype glioma

A multi-center retrospective clinical study about PTRF/Cavin-1 predicting TMZ chemotherapy sensitivity in IDH wildtype glioma

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200066884
Enrollment
Unknown
Registered
2022-12-20
Start date
2022-09-01
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

glioma

Interventions

IDH widetype glioma:no
Control samples include IDH mutant glioma and other nervous system tumors:no

Sponsors

Tianjin Medical University General Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1) Pathological diagnosis as an IDH wildtype glioma patient 2) Age between 18-60 years old 3) Given standardized temozolomide treatment after surgery 4) The follow -up time is more than 6 months

Exclusion criteria

Exclusion criteria: 1) Patients die due to stroke, myocardial infarction, accident or other clinical diseases, and have any other diseases that have malignant tumors or can interfere with the results of the test. 2) Take other chemotherapy drugs other than omolizer 3) Inadequate clinical data, lack of follow -up data 4) Researchers believe that there are other factors that are not suitable for selection. Those who meet the above conditions shall not be selected

Design outcomes

Primary

MeasureTime frame
PTRF;immune microenviroment analysis(CD68,MHCI,CD86,MHC ?,CD4,CD8 and so on);

Secondary

MeasureTime frame
DNA injury repair indicator;CD34;

Countries

China

Contacts

Public ContactKang Chunsheng
kang97061@tmu.edu.cn18622998838

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026