Linking transcriptional profile of nucleus pulposus to clinical phenotype in intervertebral disc degenerative diseases

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200066854

Enrollment

Unknown

Registered

2022-12-20

Start date

2022-12-20

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

intervertebral disc degenerative diseases

Interventions

Lumbr Cohort:Bulk RNA-seq of nucleus pulposus

Cervical Cohort:Bulk RNA-seq of nucleus pulposus

Lumbr Validation Cohort:Bulk RNA-seq of nucleus pulposus

Cervical Validation Cohort: Bulk RNA-seq of nucleus pulposus

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who need surgery treatment due to cervical and/or lumbar disc degenerative diseases meet the following criteria: 1) Age = 18 years old, voluntarily participating in this study, and donating the post operation discarded IVD tissues including nucleus pulposus, annulus fibrosus and cartilaginous endplate; 2) IVD tissue samples and clinical related data could be obtained from the subjects, including but not limited to patient epidemiological data, demographic data, clinical symptoms and signs, imaging data, laboratory examination data, histopathology, treatment methods, and other follow-up information; 3) X-ray and MRI examination profiles of cervical or lumbar spine in posterior anterior position, lateral position, and flexion and extension position. And publicly published scRNA-seq data from patients with disc degenerative diseases who met the above criteria were included.

Exclusion criteria

Exclusion criteria: Patients who met any following criteria, were excluded: 1) Infection of the target disc or its adjacent vertebrae; 2) Participating in other studies and affecting the observation of this study; 3) The subjects are not suitable to participate in the study due to high-risk diseases or other special circumstances.

Design outcomes

Primary

Measure	Time frame
nucleus pulposus transcriptome;sagittal spinopelvic parameters;histological classification for intervertebral disc degeneration;Pfirrmann classification of intervertebral disc degeneration;Demographic data;Epidemiological data of intervertebral disc degenerative diseases;	—

Countries

China

Contacts

Public ContactLiu peng

Army Medical Center of PLA

liupengd@163.com19923257587

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026