Adults with sepsis
Conditions
Interventions
Propofol group:Propofol
Sponsors
The First Affiliated Hospital of Jinan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: We will include patients who are aged 18 years or older, have sepsis (Sepsis-3 definition), need invasive mechanical ventilation for at least 24 hours, and treat with continuous sedation for safety and comfort.
Exclusion criteria
Exclusion criteria: The exclusion criteria will include (1) pregnant or breast-feeding; (2) known or suspected allergy to ciprofol or propofol; (3) psychological illness, severe cognitive dysfunction, or disorder of consciousness; (4) chronic kidney disease requiring dialysis; (5) decompensated chronic liver disease (Child-Pugh class B or C); (6) history of alcoholism or intake of anti-anxiety drugs or hypnotics; (7) body mass index=30; (8) heart rate less than 50 beats/min; (9) refractory shock (mean arterial pressure less than 60 mmHg despite appropriate intravenous volume administration and vasopressors); (10) moribund state or patients in palliative care only.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Weaning time; | — |
Secondary
| Measure | Time frame |
|---|---|
| In-hospital mortality;ICU mortality;Pain intensity;Delirium;Cognitive function;Renal function;Inflammatory markers;Immunologic markers;Sequential Organ Failure Assessment (SOFA) score;Length of hospital stay;Length of ICU stay;The doses of sedative drugs;The doses of analgesic drugs;Adverse events and serious adverse events; | — |
Countries
China
Contacts
Public ContactHai-Yan Yin
The First Affiliated Hospital of Jinan University
Outcome results
None listed