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Effect of prophylactic antibiotic use before or after endoscopic treatment on infection in patients with acute esophagogastric variceal bleeding: a multicenter, randomized, controlled study

Effect of prophylactic antibiotic use before or after endoscopic treatment on infection in patients with acute esophagogastric variceal bleeding: a multicenter, randomized, controlled study

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200066769
Enrollment
Unknown
Registered
2022-12-16
Start date
2023-01-01
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophageal and gastric varices

Interventions

The third generation cephalosporin group before operation:One time infusion of third-generation cephalosporin before emergency endoscopic treatment
Three generation cephalosporins 7 days after surgery:After emergency endoscopic treatment, the third generation cephalosporins were given intravenously for 2 days and orally for 5 days

Sponsors

Nanchong Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: ? Between 18 and 80 years old; ? Patients with acute esophagogastric fundus varices and upper gastrointestinal bleeding; Patients requiring emergency endoscopic treatment; ? Confirmation of cirrhosis: cirrhosis or portal hypertension confirmed by puncture or combined with clinical, biochemical and radiological results; ? diagnostic criteria for liver cancer: liver biopsy confirmation or imaging data combined with APF more than 400ng/ml. ? Sign informed consent.

Exclusion criteria

Exclusion criteria: ? Poor physical condition, can not tolerate gastroscopy; ? There are heart failure, COPD, non-liver malignant tumor, coagulation dysfunction, severe anemia and other organ tumor diseases, affecting gastroscopy operation or postoperative follow-up; ? Preoperative bacteriological samples (such as blood culture, ascites infection) were taken as patients with bacterial infection.

Design outcomes

Primary

MeasureTime frame
WBC;NEU%;Presence of infection;

Secondary

MeasureTime frame
HGB;PLT;PT;Brain function grading;Spontaneous peritonitis;Esophageal and gastric varices grading;Treatment under gastroscope;

Countries

china

Contacts

Public Contactzhang tao

Nanchong Central Hospital

305514271@qq.com18227312096

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026