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Effects of dexmedetomidine combined with sevoflurane pretreatment on myocardial protection and inflammatory response in patients undergoing valve replacement

Anesthesiology

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200066758
Enrollment
Unknown
Registered
2022-12-16
Start date
2022-12-16
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

valvular heart disease

Interventions

Group D:Dexmedetomidine combined with sevoflurane pretreatment
Group ND:Pretreatment with sevoflurane

Sponsors

Affiliated Hospital of North Sichuan Medical College
Lead Sponsor

Eligibility

Sex/Gender
All
Age
25 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: ? Meeting the diagnostic criteria for heart valve disease and the guidelines for valve replacement under CPB; ? The circulatory system function is stable and there is no autoimmune disease; ? Centerless cerebrovascular and other complications before operation.

Exclusion criteria

Exclusion criteria: Exclusion criteria: ?CPB shutdown failure requires CPB again; ? Reoperation after surgery; ?DEX use contraindicated; ? Body mass index =28; ? Refuse to participate in the experimenter; ? Emergency operation; ?NYHA cardiac function grade was higher than ?.

Design outcomes

Primary

MeasureTime frame
Myocardial enzyme index;IL;—

Secondary

MeasureTime frame
Postoperative recovery quality;postoperative complications;extubation time;—

Countries

China

Contacts

Public ContactDan Xie

Affiliated Hospital of North Sichuan Medical College

125840015@qq.com13541580462

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026