Patients with Graves' hyperthyroidism and mild to moderate thyroid-associated ophthalmopathy
Conditions
Interventions
Selenium treatment group:100 microgram bid
placebo:Starch 100 micrograms bid
99Tc-MDP treatment group:99Tc-MDP 20mg qod×15, intravenous infusion, 20mg qod×15 after 2 months
Sponsors
Shanghai Tenth People’s Hospital
Eligibility
Sex/Gender
All
Age
16 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Meet the diagnostic criteria for GD hyperthyroidism (GH); 2) Meet the diagnostic criteria for mild to moderate GO; 3) Over 16 years old; 4) Male and female gender is not limited; 5) 131I treatment of GH.
Exclusion criteria
Exclusion criteria: 1) Under the age of 16; 2) GO treatment such as orbital surgery and orbital irradiation; 3) Severe or severe GO or severe loss of vision; 4) Unable to agree to participate in the research; 5) The thyroid iodine uptake rate is less than or equal to 30%; 6) Selenium allergy; 7) The follow-up time is less than 6 months; 8) Treatment contraindications, such as pregnancy/pregnancy preparation, lactation, myocardial infarction, severe liver and kidney diseases, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| overall effective rate;overall effective rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| GO-QoL;GO recurrence rate;Clinical Activity Score (CAS); | — |
Countries
China
Contacts
Public ContactMa Chao
Shanghai Tenth People’s Hospital
Outcome results
None listed