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The effect of preoperative ELEVATION of CA19-9 on survival and prognosis of non-mucinous epithelial ovarian cancer in a bidirectional, observational, single-center cohort study

The effect of preoperative ELEVATION of CA19-9 on survival and prognosis of non-mucinous epithelial ovarian cancer in a bidirectional, observational, single-center cohort study

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200066721
Enrollment
Unknown
Registered
2022-12-14
Start date
2022-12-31
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-mucinous epithelial ovarian cancer

Interventions

Phase I:N/A
Phase II:N/A

Sponsors

The First Affiliated Hospital of University of Science and Technology of China
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: ? Women aged 18-90; ? After initial treatment in our hospital, non-mucinous epithelial ovarian cancer (including serous, endometrioid, clear cell carcinoma and mixed carcinoma) was confirmed by at least 2 or more physicians at the level of associate chief physicians in the department of pathology; ? Patients in the retrospective cohort were diagnosed between January 1, 2018 and December 31, 2020, and those in the validation cohort were diagnosed between January 1, 2021 and December 31, 2022; ? The level of serum CEA was normal; ? Treatment options included standard ovarian cancer staging or primary or intermediate tumor cell reduction; ? The patient's medical record information is complete, the follow-up results are complete, and the pathological report is accurate and reliable (including: Age, BMI, menopausal status, complications, primary site, tumor size, water, or intraoperative radiographic findings, lymph node metastasis and sizes before and after treatment, tumor markers, blood routine, biochemical and follow-up treatment, postoperative residual lesion size, postoperative pathology, installment, operation complexity rating, disseminated score, plan and course of chemotherapy, relapse time, Time of death etc.).

Exclusion criteria

Exclusion criteria: ? Other pathological types of ovarian malignancy (mixed ovarian tumor with mucinous exclusion); ? Have other malignant tumors or multiple primary tumors at the same time (excluding breast cancer within 2 years); ? With HIV, hepatitis B and other active infectious diseases; ? Other disease factors influencing ca19-9 values (acute pancreatitis, cholecystitis, cholestatic cholangitis, cirrhosis, hepatitis and other diseases); ? Patients who have participated in other biomedical studies or received experimental treatment in the past 30 days, unless approved by the investigator; ? The subjects are not willing to participate in the study; ? The researcher thinks that the subjects are not suitable to participate in this study.

Design outcomes

Primary

MeasureTime frame
progression-free survival;Overall survival;

Countries

China

Contacts

Public ContactZhou Ying

The First Affiliated Hospital of University of Science and Technology of China

caddiezy@ustc.edu.cn13865901025

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026