Thyroid cancer, breast cancer
Conditions
Interventions
HSK3486:Cyclopofol induction, failed to add propofol
Propofol group:Propofol induction, failed to add propofol
Sponsors
Affiliated Cancer Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Age 18-70, gender unlimited; (2) American Society of Anesthesiologists (ASA) grade I-II; (3) patients with thyroid or breast tumors requiring tracheal intubation general anesthesia for elective surgery; (4) Body mass index (BMI) =18 and =30kg/m2; (5) Vital signs: respiratory rate =10 and =24 times/min; Blood oxygen saturation (SpO2) =95% when breathing air; Systolic blood pressure (SBP) =90mmHg and =160mmHg; Diastolic blood pressure (DBP) =60mmHg and =100mmHg; Heart rate =55 and =100 beats/min; (6) Be able to understand the research process and methods, and voluntarily participate in the research.
Exclusion criteria
Exclusion criteria: (1) Patients with contraindications to general anesthesia or with a history of anesthesia accidents; (2) Known or suspected allergic or contraindicated to propofol injection, HSK3486 excipients, benzodiazepines, opioids, muscle relaxants, etc.; (3) Patients complicated with craniocerebral loss, intracranial hypertension, stroke, unstable angina pectoris, myocardial infarction; (4) Respiratory insufficiency, obstructive pulmonary disease, presence of a difficult airway, or determination of difficulty intubating (modified Marschner score Level III or IV) (5) uncontrolled diabetes or hypertension; (6) severe liver dysfunction or severe renal insufficiency; (7) A history of alcoholism or drug dependence; (8) Abuse or long-term use of narcotic, sedative and analgesic drugs; (9) previous history of mental illness; (10) Participants in any drug clinical trials within 1 month before screening; (11) Pregnant and lactating women; Fertile women or men were reluctant to use contraception throughout the trial; Subjects (including male subjects) who plan to become pregnant within 1 month after the trial; (12) Subjects with any other factors deemed unsuitable by the investigator for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Success rate of induction of anesthesia;Heart rate;Brain dual-frequency index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of injection pain;The incidence was known intraoperatively; | — |
Countries
china
Contacts
Public Contactshenglin pei
Affiliated Cancer Hospital of Guangxi Medical University
Outcome results
None listed