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Effect of epidural block combined with general anesthesia on perioperative NETosis expression in patients with colorectal cancer

Effect of epidural block combined with general anesthesia on perioperative NETosis expression in patients with colorectal cancer

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200066708
Enrollment
Unknown
Registered
2022-12-14
Start date
2022-12-16
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

colorectal cancer

Interventions

A group:Sevoflurane - opioid general anesthesia group
B group:Propofol - epidural block general anesthesia group

Sponsors

Fudan University Cancer Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Aged between 18 and 80 2.ASA grade ?-- III 3. Pathological diagnosis of colon cancer or rectal cancer 4. Patients undergoing elective open colorectal cancer surgery

Exclusion criteria

Exclusion criteria: 1. Have a history of allergy to narcotic drugs. 2. Contraindications to epidural block, such as coagulopathy, anatomic deformity, etc. 3. Unable to cooperate with the study for any reason, such as language comprehension, mental illness, etc. 4. Received chemotherapy or radiotherapy in the last 8 weeks. 5. Previous surgery for colorectal cancer. 6. History of chronic pain. 7. Body mass index >40 kg/m2

Design outcomes

Primary

MeasureTime frame
NETosis;neutrophil /lymphocyte ratio;—

Secondary

MeasureTime frame
visual analogue scale;—

Countries

China

Contacts

Public ContactZhangjun

Fudan University Cancer Hospital

snapzhang@aliyun.com13817153025

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 10, 2026