Improved skin condition
Conditions
Interventions
test group:Recombinant Collagen Injection
Control Group:In the early stage, the blank control of the experimental group was used, and in the later stage, the injection was used as the self-control before and after
Sponsors
Plastic Surgery Hospital of Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) The age is 18~65 (inclusive), gender is not limited; 2) The subject's facial skin has two or more of the following skin aging symptoms: dry skin, rough skin, fine lines, enlarged pores, dull skin, etc. Questions; 3) The skin type is Fitzpatrick skin classification ??; 4) The subject maintains the existing skin care habits throughout the test period and does not make any changes; 5) The subject voluntarily participates in this test and signs the informed consent.
Exclusion criteria
Exclusion criteria: 1) Subjects are allergic to local anesthetics (such as lidocaine, etc.) and collagen; 2) Suffer from connective tissue diseases, or suffer from scar constitution; 3) Severe heart, liver, kidney function, and blood coagulation abnormalities ( Cardiac function: Grade III and above; ALT, AST > 3 times the upper limit of normal value; serum creatinine > 1.5 times the upper limit of normal value) or history of malignant tumors (diagnosed as malignant tumors in the past 5 years, the current condition is stable and Subjects who have received appropriate treatment or resection of thyroid cancer and cervical cancer in situ); 4) One of the following conditions exists in the facial test area: a) There are significant scars, wounds, tattoos, severe acne, etc. on the face that affect the efficacy of the face Evaluator; b) active inflammation or sensitive skin in the area to be treated; c) unavoidable exposure to intense ultraviolet (UV) radiation during the study (such as sunbathers or outdoor workers); d) planning to participate in the study Major facial surgery or medical cosmetology-related treatment during the process; 5) Major facial surgery, facial filler injection, exfoliative facial photoelectric therapy and other surgical treatments in the past 3 months, or shallow chemical peeling in the past 1 month 6) Those who have used or planned to use immunosuppressants, anticoagulant drugs or used external drugs on the face (such as sugar) in the past 3 months or planned to use them in the past 1 month Corticosteroids, tretinoin ointment); 7) Women who have family planning during the study period, or women who are pregnant or breastfeeding; 8) Those who have participated in or are currently participating in drug or device clinical trials within the past month; 9) The researcher evaluates the subjects who are not suitable for participating in this trial for other reasons such as poor compliance or perception impairment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Global Aesthetic Improvement Scale, GAIS; | — |
Countries
China
Contacts
Public ContactYan Yan
Plastic Surgery Hospital of Chinese Academy of Medical Sciences
Outcome results
None listed