Chronic postsurgical pain(CPSP)
Conditions
Interventions
Esketamine group:Perioperative continuous intravenous administration of esketamine
Control group:0.9% normal saline
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1)Age=18 years old 2)Women diagnosed with primary breast cancer 3)Unilateral modified radical mastectomy for breast cancer was planned
Exclusion criteria
Exclusion criteria: 1)ASA=IV level 2)Have any contraindications to esketamine 3)Severe liver dysfunction or severe renal dysfunction 4)Previous diagnosis of mental illness and need for medication 5)Pregnancy or breastfeeding 6)Impaired communication, inability to sign informed consent form 7)Refuse to use PCIA pump 8)Refuse to participate in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of chronic pain at 3 months after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Acute pain intensity within 24 hours after surgery;QoR-15 score at 24 hours after surgery;Postoperative hospital stay;Incidence of chronic pain at 6 months after surgery;BPI pain score, interference score, and pain treatment rate at 1, 3, and 6 months after surgery;ID-Pain scores at 1, 3, and 6 months after surgery;HADS scores at 1, 3, and 6 months after surgery; | — |
Countries
China
Contacts
Public ContactLingling Wang
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed