hyperalgesia
Conditions
Interventions
ED95 Group:Intravenous esketamine during anesthesia induction
Control Group:Intravenous equivalent volume of normal saline during anesthesia induction
Experimental Group:Intravenous esketamine during anesthesia induction(ED95)
Sponsors
Affiliated Hospital of Nantong University
Eligibility
Sex/Gender
All
Age
25 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients with full ability to communicate undergoing elective laparoscopic cholecystectomy with general anesthesia, no restriction on gender, ASA status I-?, aged 25 to 75 years, BMI 20-29kg/?.
Exclusion criteria
Exclusion criteria: 1. immediate extubation was not planned after surgery 2.patients with severe preexisting cardiopulmonary, or hepatorenal dysfunction 3. allergying to esketamine, etc. 4. took analgesics regularly or had used opioids within 12 h of surgery 5. unable to comprehend visual analog scale (VAS) 6. had a history of alcohol or drug abuse, psychiatric disorder, or obesity (>130% of ideal body weight) 7. had chronic inflammatory disease 8. intraoperative changeover from laparoscopic to open cholecystectomy 9. had a condition, such as severe hypertension, acute cardiovascular disorder, or a psychiatric disorder, for which the use esketamine was contraindicated.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS Scoring;ED50 by sequential approach; | — |
Secondary
| Measure | Time frame |
|---|---|
| Demographic data;Intraoperative outcomes;Adverse effects;Vital signs;Prognosis of the studied patients;Resuscitation situations; | — |
Countries
China
Contacts
Public ContactZhongLing Xu
Affiliated Hospital of Nantong University
Outcome results
None listed