Patients with acute and chronic pain after laparoscopic sleeve gastrectomy
Conditions
Interventions
S Group:Sufentanil + Esketamine
C Gruop:Sufentanil + Sodium chloride injection
Sponsors
The Third Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18-65 years; 2.ASA I - ? level; 3.Elective laparoscopic sleeve gastrectomy; 4.Patients voluntarily participated in the study and signed written informed consent
Exclusion criteria
Exclusion criteria: 1. history of chronic pain ( >3 months ); 2. Severe disease (ASA grade =IV), severe renal insufficiency (preoperative dialysis), severe liver insufficiency (Chlid-Pugh grade C); 3. Patients with central nervous system diseases, mental system diseases (schizophrenia, mania, insanity, etc.), long-term use of sedatives, craniocerebral injury and/or cerebrovascular accident history, possible intracranial hypertension, cerebral aneurysm, glaucoma, etc; 4. Patients with poorly controlled or untreated hypertension (resting systolic blood pressure greater than 180 mmHg or resting diastolic blood pressure greater than 100 mmHg), heart failure (NYHA class III-IV), unstable angina pectoris, and prolonged QT interval on ECG: Men with QT interval ?450ms, women with QT interval?470ms, third degree atrioventricular block and other severe arrhythmias, severe heart valve disease (such as moderate or more valve insufficiency or stenosis, or multiple valve disease); 5. Long-term preoperative use of analgesics, non-steroidal drugs, and allergic or contraindicated to esketamine, opioids, propofol, haloperidol and other drugs and their drug components; 6. Patients transferred to ICU after operation; 7. Patients who are unwilling to use PCIA or refuse to participate in this study; 8. Other conditions deemed unsuitable for inclusion by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Opioid dose at 48 hours after operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain scores at 2 hours, 6 hours, 1 day, 2 days, 7 days, 1 month, 3 months, 6 months, and 12 months after operation;GAP-7/PHQ-9 scores and sleeping scores at 1 day, 2 days, 1 day, 2 days, 7 days, 1 month, 3 months, 6 months and 12 months after surgery;Health status score at 7 days, 1 month, 3 months, 6 months and 12 months after operation;Agitation and sedation were evaluated at 2 hours, 6 hours, 1 day, and 2 days after operation;Incidence of adverse reactions (nausea, vomiting, dizziness);Time of first postoperative anal exhaust; | — |
Countries
China
Contacts
Public ContactLiaojuan
The Third Xiangya Hospital of Central South University
Outcome results
None listed