Patients with moderate and severe edema of CKD
Conditions
Interventions
Tolvaptan alone treatment group:Tolvaptan
Tolvaptan combined with low-dose loop diuretics treatment group:Tolvaptan combined with loop diuretics
loop diuretic alone treatment group:loop diuretic
Sponsors
China-Japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1) Age = 18 years old and = 85 years old, regardless of gender; 2) Patients who meet the diagnostic criteria of chronic kidney disease and have moderate or above edema; 3) Voluntarily participate in this experiment, understand and sign the informed consent form; 4) The subjects were able to complete the study in accordance with the provisions of the study.
Exclusion criteria
Exclusion criteria: 1) Severe liver function damage, child Pugh grade C (10 points or higher); 2) Low blood volume status assessed clinically; 3) Hypernatremia; 4) Recent use of nephrotoxic drugs; 5) Unable to cope with thirst, or unable to perceive thirsty objects; 6) Any major history of drug allergy; 7) Any situation that the researcher believes is not suitable for participating in the study; 8) The patients who participated in the study were employees of the center or relatives of researchers; 9) Participate in clinical research of other drugs or devices; 10) Any disease or condition that reduces the life expectancy of the patient. 11)Dialysis patients, patients with kidney diseases and immune diseases, patients with hormone and immunosuppressive drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| estimated glomerular filtration rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum creatinine;Cystatin C;serum total protein;albumin;brain natriuretic peptide;NT-proBNP;Blood potassium and sodium;blood clotting;24-hour cumulative urine volume;24-hour urinary protein quantitation;weight;Edema score; | — |
Countries
China
Contacts
Public ContactLi Zhou
China-Japan Friendship Hospital
Outcome results
None listed