Sepsis
Conditions
Interventions
TEN:Total enteral nutrition was given
TPN:Total intravenous nutritional support was given
SPN:Nutritional support was given by enteral nutrition support + parenteral nutrition support
Sponsors
General Hospital of Ningxia Medical University
Eligibility
Sex/Gender
All
Age
43 Years to 75 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria are as follow: (1) aged 18-75 years; (2) have met the latest definition of sepsis of the American Society of Critical Care Medicine "Sepsis-3.0" from 2016[1]; (3) mechanically ventilated patients; and (4) indicated for nutritional support (hemodynamic stability [no dose or small dose of vasoactive drugs to maintain vital signs and lactate = 2 mmol/L] and NUTRIC score [Nutritional Risk Rating Instrument for Critically Ill Patients] = 6).
Exclusion criteria
Exclusion criteria: The exclusion criteria are as follow: (1) those with chest wall, thoracic, or airway injuries, respiratory instability, ventilator parameters requiring adjustment during measurement, or rapid respiratory rate = 35 breaths/min, or oxygen concentration > 60%, or positive end-expiratory pressure = 10 cmH2O; (2) those with open injuries to the gastrointestinal tract or abdominal cavity; and (3) those whose family members did not provide informed consent. Informed consent was obtained from patients or immediate family members.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fecal 16s-rRNA sequencing;Fecal short-chain fatty acids;Blood nutrition and immune indicators; | — |
Countries
China
Contacts
Public ContactXiaoJuan Yang
General Hospital of Ningxia Medical University
Outcome results
None listed