Gastroesophageal reflux disease
Conditions
Interventions
esomeprazole group:esomeprazole 20mg qd po,4 weeks
vonoprazan group:vonoprazan 20mg qd po,4 weeks
Sponsors
The University of Hong Kong-Shenzhen Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) =20 years old; 2) GERD Q score =8, among which heartburn and/or reflux score =2.
Exclusion criteria
Exclusion criteria: 1) Esophageal/gastric/duodenal surgery history, esophageal stricture, pyloric stricture, achalasia of cardia, gastric or duodenal ulcer, acute gastritis, Zollinger-Ellison syndrome, inflammatory bowel disease and other gastrointestinal diseases; Diabetes, hypertension; Other serious diseases (liver, kidney, respiratory or heart disease); History of malignancy; Diseases of the blood system; Pregnancy/lactation; Chronic smoking and drinking; 2) A long history of using the following drugs: calcium antagonists, diazepam, ß-agonists, a-receptor antagonists, anticholinergics, theophylline, tricyclic antidepressants, dopamine receptor agonists, and other drugs that may affect cytochrome P450 2C19(CYP2C19) enzyme; Allergic history of PPIs; 3) Acid suppressant drugs (PPIs, H2RA, Vonorosen) have been taken in the past 1 week.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GERD Q score; | — |
Secondary
| Measure | Time frame |
|---|---|
| FSSG score;Nighttime sleep questionnaire; | — |
Countries
China
Contacts
Public ContactTao Lv
The University of Hong Kong-Shenzhen Hospital
Outcome results
None listed