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Comparison of the effects of oxidized regenerated cellulose and topical tranexamic acid on bleeding in total knee arthroplasty—a prospective randomized controlled trial

Comparison of the effects of oxidized regenerated cellulose and topical tranexamic acid on bleeding in total knee arthroplasty—a prospective randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200066633
Enrollment
Unknown
Registered
2022-12-12
Start date
2022-12-15
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee arthritis

Interventions

Group B:Topical use of oxidized regenerated cellulose
Group C:Tranexamic acid 2 g topically
Group A:Blank control

Sponsors

Xi'an Honghui Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients who underwent unilateral primary total knee replacement in Xi'an Red Society Hospital from December 15, 2022 to March 15, 2023

Exclusion criteria

Exclusion criteria: 1. Preoperative anemia (male 1.4, activated partial thromboplastin time (APTT) >1.4× normal, platelet <140,000/mm3) 9. Intraoperative complications (fractures, etc.)

Design outcomes

Primary

MeasureTime frame
haemoglobin;—

Secondary

MeasureTime frame
hematocrit;platelet;C-reactive protein;erythrocyte sedimentation rate;—

Countries

China

Contacts

Public ContactBowei Li

Xi'an Medical College Hanguang Campus/ Xi'an Honghui Hospital

1242593307@qq.com15353546213

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026