General anesthesia for elderly patients
Conditions
Interventions
Etomidate group:etomidate TCI
Propofol group:Propofol TCI
Etomidate combined with propofol group:Etomidate combined with propofol TCI
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: a. patients scheduled for urological surgery; b. Aged 65 to 85 years old,gender unlimited; c. Body mass index (BMI) 18.5-30 kg/m2; d. American Society of Anesthesiologists (ASA) grade ?~?; e. New York Heart Association (NYHA) functional class ?~?; f. Duration of surgery less than 4 hours.
Exclusion criteria
Exclusion criteria: a. Patients with severe cerebral, pulmonary, hepatic, renal and metabolic diseases; b. Patients with acute inflammation of the respiratory tract within 2 weeks without cure and asthma; c. Preoperative patient SBP more than 180mmHg or DBP more than 110mmHg, or patients with hypotension less than 90/60 mmHg. d. Patients with anemia and abnormal coagulation function; e. Patients with neuromuscular diseases or mental disorders; f. Patients are suspected abuse of narcotic analgesics or sedatives; g. Patients who are allergic to the test drugs, with allergic diseases, or are allergic constitution; h. patients with adrenal diseases and immune diseases; i. patients had taken glucocorticoids or other immunosuppressive drugs within 6 months; j. Patients who declined to participate in this trial; k. Patients are uncooperative or inability to communicate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| dosage of anesthesia maintenance drugs;Blood pressure and heart rate;Oxygen saturation;Hemodynamic change; | — |
Secondary
| Measure | Time frame |
|---|---|
| Use of vasoactive drugs; | — |
Countries
China
Contacts
Public ContactShen Qiying
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed