The effect of intraoperative intravenous lidocaine infusion on short-term recovery and long-term prognosis of patients with lung cancer: a prospective, randomized, controlled clinical trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200066615

Enrollment

Unknown

Registered

2022-12-12

Start date

2022-12-01

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung cancer

Interventions

Lidocaine group:Intraoperative intravenous lidocaine infusion

Control goup:Intraoperative intravenous normal saline infusion

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Individuals aged from 18 to 80 year-old who have lung cancer with clinical Stage II and IIIa amenable for video-assisted thoracoscopic tumor resection with curative intention will be included.The clinical stage classification refers to the 8th edition of lung cancer stage classification released by International Association for the Study of Lung Cancer (IASLC) in 2017. 2.Participants will be required to pass functional respiratory tests with forced expiratory volume at one second > 50% or forced vital capacity > 50% preoperatively. 3.All participants will be voluntary and asked to sign the informed consent form before investigation.

Exclusion criteria

Exclusion criteria: (a) Concurrent malignancies or with distant metastasis (b) Undergoing emergency surgery (c) Pregnancy or lactation (d) History of heart disease (coronary artery disease, heart valve disease, and/or history of arrhythmia) (e) Inability to undergo mechanical ventilation for pulmonary protection (f) Severe neurologic conditions, severe renal or liver insufficiency (creatinine >186 mmol L-1, bilirubin >20 mmol L-1, or plasma albumin <30 g L-1) (g) History of autoimmune disease or receiving chronic treatment of corticosteroids or immunosuppressants 3 months before surgery (h) Suffering from chronic pain within a long-term oral analgesicis treatment (i) Transfusion of blood products in the past 10 days (j) American Society of Anesthesiologists (ASA) physical status classification of IV or higher (k) Inappropriate for epidural anaesthesia (l) Lidocaine sensitivity or allergy

Design outcomes

Primary

Measure	Time frame
Overall survival;Disease free survival;	—

Secondary

Measure	Time frame
Acute postoperative pain;Choronic postsurgical pain;Perioperative opioid use;Incidence of Postoperative complications;Length of stay;	—

Countries

China

Contacts

Public ContactChanghong Miao

Zhongshan Hospital, Fudan University

miaochangh@163.com13681975062

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026