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Study on the function and mechanism of macrophages and extracellular histones in different periods before and after organ transplantation

Study on the function and mechanism of macrophages and extracellular histones in different periods before and after organ transplantation

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200066601
Enrollment
Unknown
Registered
2022-12-11
Start date
2022-12-11
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

End stage renal disease

Interventions

1:Blood, urine and puncture samples were collected to detect extracellular histones, inflammatory factors, macrophage subtypes, transcriptome, related RNA, macrophage infiltration and typing.

Sponsors

The Second Affiliated Hospital of Hainan Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: ?Patients with end-stage renal disease who plan to undergo kidney transplantation in our hospital; ?Patients who voluntarily participate, have good compliance, and sign informed consent.

Exclusion criteria

Exclusion criteria: ?The patient is under the age of 16. ?Patients have undergone multiple organ transplantation or secondary transplantation. ?Patients do not cooperate with follow-up experiments. ?Those considered inappropriate by the researchers.

Design outcomes

Primary

MeasureTime frame
Concentration of extracellular histones in peripheral blood;Macrophage subtype;gene transcriptomics;Degree of macrophage infiltration;blood biochemical indicators;Liver and kidney function;dd-cfDNA;—

Countries

China

Contacts

Public ContactJiang Hongtao

The Second Affiliated Hospital of Hainan Medical University

jht20032003@163.com13973404925

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026