Induction of general anesthesia
Conditions
Interventions
Group A(18-29 years):Remazolam 0.2mg/kg intravenously
Group B(30-39 years): Remazolam 0.2mg/kg intravenously
Group C(40-49 years): Remazolam 0.2mg/kg intravenously
Group D(50-59 yaers):Remazolam 0.2mg/kg intravenously
Group E(60-69 years):Remazolam 0.16mg/kg intravenously
Group F(70-79 years):Remazolam 0.10mg/kg intravenously
Group G(>80 years):Remazolam 0.10mg/kg intravenously
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Adults with normal mental and physical development,ASA grade ?-?, who needed to undergo examination/surgery due to their condition in the day surgery center and operating room of our hospital were selected.
Exclusion criteria
Exclusion criteria: Age < 18 years; Allergic to benzodiazepines and any ingredient of this product; Mental health problems; Severe respiratory diseases; Serious cardiovascular diseases; Severe liver and kidney dysfunction; Patients with myasthenia gravis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Half effective dose of rimazolam for loss of consciousness in patients of different ages;Loss of consciousness (MOAA/S score =1 within 3 minutes after intravenous remazolam);Incidence of adverse reactions: injection pain, hiccup, body movement, increased speech, muscle fibrillation, respiratory depression (SPO2<90%, RR<10 times/min), cough, awareness; | — |
Secondary
| Measure | Time frame |
|---|---|
| The induction dose;BIS score;Give remazolam until you lose consciousness;After entering the operating room, the baseline value (T0) and the administration of remazolam were Carve RR, SpO?, HR, and MAP for (T1), 1min(T2), 2min(T3), and 3min (T4).; | — |
Countries
China
Contacts
Public ContactYunan Lin
The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed