Depression
Conditions
Interventions
Propofol-ketamine group:Intravenous anesthesia with propofol and s-ketamine
S-ketamine group:Intravenous anesthesia with s-ketamine
Sponsors
The First Hospital of Shanxi Medical University
Eligibility
Sex/Gender
All
Age
12 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age= 12 years old; 2. Patients diagnosed with major depressive disorder using DSM-V or CCMD-3; 3. Patients and their families voluntarily participate and sign informed consent;
Exclusion criteria
Exclusion criteria: 1. Patients with serious physical diseases such as coronary heart disease, asthma, intracranial vascular malformations, and uncontrolled hypertension; 2. History of previous insufficiency of heart, liver, kidney and other organs; 3. There are foreign bodies such as pacemakers and intracranial electrodes in the body; 4. Those who are allergic to the anesthetic drugs of this study; 5. Those with a history of substance abuse; 6. People with other mental illnesses, such as schizophrenia, obsessive-compulsive disorder, anorexia nervosa, etc.; 7. Combined with other diseases that affect the assessment of cognitive function, such as cerebral infarction, brain retardation, trisomy 21, etc.; 8. History of ECT treatment in the past 3 months; 9. Women who are pregnant.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression Scale score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive scale scores;Electroconvulsive therapy indicators;Electroconvulsive therapy anesthesia indicators;Incidence of adverse reactions;Serological indicators; | — |
Countries
China
Contacts
Public ContactZhang Yanqing
The First Hospital of Shanxi Medical University
Outcome results
None listed