postoperative delirium
Conditions
Interventions
Experimental group:Dextrmedetomidine+dexamethasone
Control group:None
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 65 years; 2. Elective operation for hip fracture under general anesthesia; 3. Corrected vision and hearing are basically normal, and can complete cognitive assessment; 4. ASA grade I to III.
Exclusion criteria
Exclusion criteria: 1. Previous history of neurological diseases such as craniocerebral tumor, cerebral hemorrhage, massive cerebral infarction, or mental illness such as depression and dementia; 2. Postoperative severe anxiety and depression or pulmonary infection, pulmonary embolism, cerebral infarction and other serious complications; 3. Participating in other clinical trials; 4. Cognitive impairment, MMSE<=23; 5. There are multiple fractures; 6. Patients who are allergic to glucocorticoid drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium;Severity of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemoglobin;Neutrophil granulocyte;Lymphocyte cell;Blood glucose;Pain score;C-reactive protein;Urea nitrogen/creatinine;Albumin;Albumin/globulin;D-dimer;Blood loss volume;Total fluid infusion volume;Blood infusion;Blood pressure;Temperature;Length of operation;Length of stay; | — |
Countries
China
Contacts
Public ContactZhao Xuan
Shanghai Tenth People's Hospital
Outcome results
None listed