Autism-spectrum disorder
Conditions
Interventions
Small-aged control group:Oral placebo
Small age experimental group:Oral of Lactobacillus plantarum PS128
Older experimental group:Oral of Lactobacillus plantarum PS128
Older control group:Oral placebo
Sponsors
Dalian Women and Children's Medical Center (Group)
Eligibility
Sex/Gender
All
Age
2 Years to 7 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for autism in children of the American Diagnostic and Statistical Manual of Mental Disorders (DSM-5) and the diagnostic criteria for Classification and Diagnosis of Mental Disorders (CCMD-2); 2. Childhood autism rating scale (CARS) >=30 points; 3. Aged 2-7 years (less than 7 years old), no gender limit.
Exclusion criteria
Exclusion criteria: 1. Other widespread developmental disorders and autism with a clear genetic cause; 2. Antibiotics, probiotics or other gastrointestinal treatments were used within 1 month before enrollment; 3. Patients with epilepsy, ADHD and other comorbid diseases; 4. Any behavior that prevents the principal investigator of the clinical study from interpreting the results of the clinical judgment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Social Responsiveness Scale, SRS;Child Behavior Checklist, CBCL;Autism Behavior Checklist, ABC;The arrival time of the first gaze was measured by an eye tracker;The duration of the first fixation point was measured by the eye tracker; | — |
Countries
China
Contacts
Public ContactSun Jin
Dalian Women and Children's Medical Center (Group)
Outcome results
None listed