Acute ischemic stroke
Conditions
Interventions
Sponsors
Weihai Municipal Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Aged >=18 years; 2. The time from onset to randomization is within 24 hours; 3. According to clinical symptoms or imaging examination, it was preliminarily diagnosed as anterior circulation great vessel occlusive stroke; 4. NIHSS score >5; 5. Score of ASPECTS >=5 points; 6. CTA/ MRA/ DSA confirmed occlusion of intracranial segments of internal carotid artery and M1 and M2 segments of middle cerebral artery, and decided to perform endovascular therapy; 7. Written informed consent signed by patient or family member.
Exclusion criteria
Exclusion criteria: 1. Skull computed tomography (CT) or magnetic resonance imaging (MRI) confirmed intracranial hemorrhage; 2. Patients with unvascularized blood vessels after dissolution/thrombectomy, failure of reperfusion or bleeding transformation after reperfusion resulted in serious condition and were not suitable for MRI outside; 3. mRS Score >=2 before onset; 4. Pregnant patients, positive pregnancy test and lactating patients; 5. Patients with coagulation disorders and metabolic diseases; 6. Patients with chronic hemodialysis and severe renal insufficiency (glomerular filtration rate 220µmol/L (2.5mg/dl)); 7. Patients with liver insufficiency; 8. Patients who do not comply with study procedures due to alcoholism, drug dependence, non-compliance with medical advice or other reasons, and patients who are not expected to complete follow-up; 9. Brain tumors and tumors of other tissues and organs of the body with space occupying effect on imaging; 10. Patients with systemic infectious diseases, AIDS and other infectious diseases; 11. Patients suffering from mental illness and mental disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified Rankin Scale (MRS) Score;National Institute of Health Stroke Scale Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| serum lactate;serum glucose; | — |
Countries
China
Contacts
Public ContactWang Pengfei/Xiong Xiaoyi
Weihai Municipal Hospital/ Chengdu University of Traditional Chinese Medicine
Outcome results
None listed