Alzheimer's disease (AD)
Conditions
Interventions
Experimental group:Zhinao capsule (0.4g/ pill, orally, 3 capsules per time, 3 times a day) + Donepezil tablets (5mg/ pill, orally, 1 tablet per time, taken before going to bed at night, the dose was m
Control group:Zhinao capsule simulator (oral, 3 capsules a time, 3 times a day) + Donepezil tablets (5mg/ tablet, orally, 1 tablet a time, before going to bed at night, the dose maintained for 4 weeks
Sponsors
The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
45 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria of AD Western medicine; 2. Aged between 45 and 85 years; 3. The Simple Mental State Scale (MMSE) was 10 to 26 points, indicating mild and moderate AD; 4. CDR score dementia belongs to mild and moderate patients (CDR equals 1.0 or 2.0); 5. Hachinski ischemia scale is less than or equal to 4 points; 6. Hamilton depression scale is less than or equal to 7 points; 7. Brain MRI showed reduced volume of hippocampus or atrophy of medial temporal lobe; 8. The patient or legal representative shall give informed consent and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Those who have no reliable care; 2. Complicated with serious primary diseases of the heart, brain, liver, kidney and hematopoietic system; 3. Mental patients; 4. Long-term use of traditional Chinese medicine for the treatment of AD affects the efficacy evaluation; 5. Allergic constitution or allergic to test drugs; 6. Patients with severe gastric and duodenal diseases affecting drug absorption; 7. Currently participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alzheimer's Disease Rating Scale-Cognition (ADAS-cog);Clinical Dementia Rating Scale (CDR);Alzheimer's Disease Syndrome Factor Scale (AD-PS-11); | — |
Secondary
| Measure | Time frame |
|---|---|
| Activities of Daily Living (ADL);Mini-mental State Examination (MMSE);Montreal Cognitive Assessment Scale (MoCA); | — |
Countries
China
Contacts
Public ContactXie Wenting, Yang Wenming
The First Affiliated Hospital of Anhui University of Chinese Medicine
Outcome results
None listed