coronary heart disease
Conditions
Interventions
HA group:Using HA380 hemoperfusion 300ml/min, = 1.5 hours during cardiopulmonary bypass
Control group:None
Sponsors
Xiangya Hospital,Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) Adult patients >= 18 years old; 2) History of antiplatelet aggregation therapy with aspirin and/or clopidogrel before operation; Emergency open heart surgery is planned if the drug withdrawal time less than 7 days; 3) Preoperative basic value: albumin concentration >= 35g/L, platelet count >= 100 × 109/L, hemoglobin concentration = 120g/L; 4) The patient voluntarily participated in the trial and signed the informed consent form
Exclusion criteria
Exclusion criteria: 1) Allogeneic blood was transfused from preoperative before termination of cardiopulmonary bypass. 2) A large amount of accidental blood loss >= 500ml during operation cannot be retrived; The postoperative survival time was less than 48 hours; 3) If heparin resistance accuring, other anticoagulants were used to replace heparin, fibrinogen was used, or albumin was transfused, and autologous plateletpheresis were applied and reinfused intraoperatively; 4) Patients and their families refused to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| volume of 24h drainage; | — |
Secondary
| Measure | Time frame |
|---|---|
| Types of allogeneic blood transfusion 0-7 days perioperatively;Total number of allogeneic blood transfusion 0-7 days perioperatively;ICU stay;duration of mechanical ventilation;albumin;number of platelets; | — |
Countries
China
Contacts
Public ContactLian Duan
Xiangya Hospital, Central South University
Outcome results
None listed