respiratory distress syndrome
Conditions
Interventions
HHHFNC group:The initial respiratory support was HHHFNC mode
NCPAP group:The initial respiratory support was CPAP mode
Sponsors
Shenzhen Second People's Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: A. Gestational age 28-36+6 weeks. B. Meet the RDS diagnostic criteria of Practical Neonatology (5th edition) : a. Progressive dyspnea of premature infants after birth; b. Chest X-ray findings consistent with RDS: C. within 6 h after birth into the line of endotracheal intubation and noninvasive respiratory support, inhaled oxygen concentration (fraction of inspired oxygen, FiO2) ? 30%.
Exclusion criteria
Exclusion criteria: A. Children who require or have been intubated immediately after birth; B. Children with respiratory distress due to severe infection, aspiration pneumonia asphyxia, congenital pneumonia and other causes; C. Complicated with severe congenital malformations (such as cyanosis congenital heart disease, congenital pulmonary dysplasia, respiratory malformations, esophageal fistula, etc.); D. Meconium inhalation syndrome, early-onset sepsis, severe intracranial blood; E. congenital hereditary ejection; F. Endotracheal intubation mechanical ventilation was required at postnatal resuscitation and exogenous PS was used before admission; G.Neonatal pulmonary hemorrhage, cardiac arrest, cardiopulmonary resuscitation, still does not establish effective spontaneous breathing in children.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reintubation rate within 72 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood Gas Analysis;Utilization rate of Poractant Alfa Injection;Incidence of complications;Time of oxygen therapy;mortality rate;the score of NBNA;Skull color ultrasound or magnetic resonance imaging;Bailey Infant Neurodevelopmental Score;Indicators of moisture respiratory lung function;The incidence of asthmatic disease; | — |
Countries
China
Contacts
Public ContactBai Yuxin
Shenzhen Second People's Hospital
Outcome results
None listed